case study

The Impact of Oral Polypodium Leucotomos Extract on Ultraviolet B Response: A Human Clinical Study

Background:

There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.

Objective:

This study was designed to objectively evaluate the molecular and photobiologic effects of oraladministration of Polypodium leucotomos extract (PLE).

Methods:

In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation wasdone immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.

Limitations:

Only 2 doses of PLE were given. Furthermore, subjects with skin photo types I to III only were studied.

Conclusion:

The results suggest that PLE can potentially be used as an adjunctive agent to lessen thenegative photobiologic effects of UVB.

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