case study

Oral Polypodium Leucotomos Extract Decreases Ultraviolet-Induced Damage of Human Skin.

BACKGROUND:

UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits. Objective: We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL).

METHODS:

A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin.

RESULTS:

A significant decrease in erythema was found in PL-treated skin (P < .01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P < .05), cyclobutane pyrimidine dimers (P < .001), proliferating epidermal cells (P < .001), and dermal mast cell infiltration (P < .05). A trend toward Langerhans cell preservation was seen.

CONCLUSION:

Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation.

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